Jesus - Family - Opposition

Just how did opposition to Jesus emerge, and when, and why? It is self-evident that a Temple-observant and synagogue attending tradesman from the back roads would be known by few. Surely Jesus lived and worked in Nazareth as a young man, well-regarded by folk (so, Luke 2). When Jesus was about 30 came the call of John the Baptist and Jesus’ acceptance of John’s baptism of repentance.   

Then something changed.